Acute Megakaryoblastic Leukemia Associated with Sweet's Syndrome, Including Review of the Literature.
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- YOKOYAMA Kenji
- Department of Internal Medicine, Ashikaga Red Cross Hospital
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- KOJIMA Masaru
- Department of Pathology, Ashikaga Red Cross Hospital
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- KOMATSUMOTO Satoru
- Department of Internal Medicine, Ashikaga Red Cross Hospital
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- NARA Masaharu
- Department of Internal Medicine, Ashikaga Red Cross Hospital
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- OHYASHIKI Kazuma
- First Department of Internal Medicine, Tokyo Medical College
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- IKEDA Yasuo
- Department of Internal Medicine, Keio University School of Medicine
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- TOYAMA Keisuke
- First Department of Internal Medicine, Tokyo Medical College
Bibliographic Information
- Other Title
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- Ｓｗｅｅｔ症候群が合併した急性巨核芽球性白血病の１例 文献的考察を含めて
- —文献的考察を含めて—
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Abstract
A case of Sweet syndrome (SS) associated with acute megakaryoblastic leukemia (AMKL) is reported. A 66-year-old male was admitted to Ashikaga Red Cross Hospital because of skin eruption and sore throat. His eruption was tender and erythema-like nature. He developed a spiking fever after admission. CBC revealed pancytopenia, and a bone marrow specimen showed increased megakaryoblasts and fibrosis. These blasts were shown to be CD41-positive by flow cytometric analysis. A diagnosis of AMKL was then made. Skin biopsy revealed infiltration of nerutrophils without vasculitis, compatible with SS. Oral administration of prednisolone was begun which improved his skin lesions considerably. He was then treated with low dose Ara-C, which was however ineffective. The blasts increased in the peripheral blood and he died on the 72nd hospital day. There are 37 reported cases of SS associated with acute nonlymphocytic leukemia, and this is the first case report of SS associated with AMKL.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 34 (3), 341-347, 1993
The Japanese Society of Hematology