Minimally Differentiated Hypoplastic Leukemia.

DOI PubMed 2 Citations 15 References
  • MITSUHASHI Shoichi
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
  • NAGASAWA Toshiro
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
  • KAMOSHITA Masaharu
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
  • OTANI Koji
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
  • HASEGAWA Yuichi
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
  • KOJIMA Hiroshi
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
  • NINOMIYA Haruhiko
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba
  • NAKAZAWA Masaki
    Department of Internal Medicine, Yamanashi Social Health Insurance Hospital
  • ABE Tsukasa
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba

Bibliographic Information

Other Title
  • 微分化型低形成性急性白血病の１例

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Description

Sixty-seven years-old female, who was an atomic bomb survivor in Hiroshima, was pointed out as having leukopenia and anemia in 1991. She was referred to Tsukuba University Hospital in June 1992. Her peripheral blood count showed pancytopenia- 2,600/μl WBC, 10.5 g/dl hemoglobin, and 80,000/μl platelets- at that time. BM biopsy revealed hypoplastic marrow and increased peroxidase-negative blasts (32.8%). Surface marker analysis of the blasts showed a feature of CD2+ CD33+ CD34+ CD13+ CD3-. Electronmicroscopically, myeloperoxidase was positive. She was diagnosed as having hypoplastic leukemia of which the blasts had a feature of AML-M0 by FAB-group. After 6 months' silent period, her pancytopenia became profound. We successfully reduced the blasts by BAM therapy. However, she died of bacterial pneumonia during the myelosuppressive state. This is a case of minimally differentiated hypoplastic AML.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 36 (2), 115-120, 1995

    The Japanese Society of Hematology

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