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- MURATA Michio
- Department of Internal Medicine, Kagawa Medical School
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- NAGAI Masami
- Department of Internal Medicine, Kagawa Medical School
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- TASAKA Taizo
- Department of Internal Medicine, Kagawa Medical School
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- OHNISHI Hiroaki
- Department of Internal Medicine, Kagawa Medical School
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- SASAKI Kazunori
- Department of Internal Medicine, Kagawa Medical School
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- TAOKA Teruhisa
- Clinical Laboratory Medicine, Kagawa Medical School
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- IKEDA Kazuma
- Transfusion Medicine, Kagawa Medical School
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- KUBOTA Yositsugu
- Department of Internal Medicine, Kagawa Medical School
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- TANAKA Terukazu
- Department of Internal Medicine, Kagawa Medical School
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- TAKAHARA Jiro
- Department of Internal Medicine, Kagawa Medical School
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- IRINO Shozo
- Department of Internal Medicine, Kagawa Medical School
Bibliographic Information
- Other Title
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- DCVP-l-asp療法による成人急性リンパ性白血病の治療成績
- DCVP-1-asp療法による成人急性リンパ性白血病の治療成績
- DCVP-1 asp リョウホウ ニ ヨル セイジン キュウセイ リンパセイ
Search this article
Abstract
From 1985 to 1991, 20 patients with adult acute lymphoblastic leukemia (ALL) were treated with the DCVP-1-asp protocol, which consists of daunorbicin, cytosine arabinoside, vincristine, prednisolone, and I-asparaginase. of these 17 patients (85%) achieved complete remission. A Kaplan-Meier analysis predicted that 30% of the patients in remission would remain disease-free at 5years. Four patients relapsed between 1 and 2.5 years from the start of treatment. The median survival time for the four patients with an abnormal karyotype was 15 months. No meningeal relapses occurred in patients treated with regular CNS prophylaxis. Myelosuppression was severe, but was well tolerated with supportive therapy, and there were no treatment-related deaths. We conclude that DCVP-1-asp is a feasible and effective protocol for adult ALLs including elderly patients. However, new treatment modalities, such as bone marrow transplantation, should be explored in patients with unfavorable prognostic factors.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 34 (3), 307-312, 1993
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390001205027967744
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- NII Article ID
- 130004919247
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:DyaK3s3ktVOjsg%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 3816072
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- PubMed
- 8479082
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed