Analysis of T Cell Subsets in Autoimmune Hemolytic Anemia Patients

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  • IWASE Osamu
    The First Department of Internal Medicine, Tokyo Medical College
  • AOKI Isao
    The Second Department of Internal Medicine, Kyorin University, School of Medicine
  • KURIYAMA Yuzuru
    The First Department of Internal Medicine, Tokyo Medical College
  • UCHIDA Yoshiko
    The First Department of Internal Medicine, Tokyo Medical College
  • AIZAWA Shin
    The First Department of Internal Medicine, Tokyo Medical College
  • NAKANO Masaru
    The First Department of Internal Medicine, Tokyo Medical College
  • TOYAMA Keisuke
    The First Department of Internal Medicine, Tokyo Medical College

Bibliographic Information

Other Title
  • 自己免疫性溶血性貧血におけるT細胞サブセットの検討
  • ジコ メンエキセイ ヨウケツセイ ヒンケツ ニ オケル Tサイボウ サブセット

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Abstract

To clarify a role of immunoregulatory T cells in the pathophysiology of autoimmune hemolytic anemia (AIHA), we investigated T cell subsets in the peripheral blood of 15 patients with AIHA by two color analysis using flow cytometry. Consequently both CD4+ cells and CD4+CD45RA+ cells decreased in proportion, irrespective of the disease activity (active or remission phase). CD4+CD45RA+ cells are regarded as naive T cells. Incidentally the ratio of CD45RA+ cells in CD4+ cells also fell in the low level in active phase, but it recovered to the normal ratio in remission. On the other hand, CD8+ cells and CD8++S6F1+ cells that may represent activated cytotoxic T lymphocytes increased in active phase and then both entered the normal range in remission. These findings suggest that AIHA could be caused partly by the alternative balance of CD4+CD45RA+cells probably constituting a member of IRT and moreover by the activation of CTL.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 36 (1), 1-5, 1995

    The Japanese Society of Hematology

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