Myelodysplasia with Hypoplastic Marrow

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  • Myelodysplasia with Hypoplastic Marrowの検討

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Abstract

In this paper, clinical and hematological findings of 4 patients showing myelodysplasia with hypoplastic marrow (Group A) were compared with those of 8 patients diagnosed to be myelodysplastic syndromes (MDS) according to FAB classification (Group B). Cytopenia and morphological anomalies in 2 or 3 blood cell lines, corresponding to hematological characteristics of MDS, were found in all patients in Group A.<br>The results included followings; (1) Age distribution in Group A and B showed no significant difference. Male and female ratio was 5: 3 in Group B. On the other hand, all were male in Group A. The interval between the onset of initial symptom and diagnosis tended to be longer in Group A than that in Group B (9 vs 5.5 months in median). (2) In Group B, 5 patients were classified as RAEB and 3 patients as RAEB-T according to FAB criteria. In Group A, hematological findings were similar to RAEB in all patients except for hypoplastic marrow. Although the degree of anemia was at most equal in both groups, leukocytopenia and thrombocytopenia were somewhat more severe in Group B. (3) During the clinical observation, one patient terminated in acute leukemia (M2) in Group A and B, respectively. A clonological change, hypoplastic to hyperplastic marrow, was observed in one patient in Group A. The median survivals from the onset of initial symptom and from the diagnosis were 23.5+ and 14+ months, respectively. On the other hand, they were 10+ and 6+ months in Group B. The study on clinical and hematological findings could not disclose significant differences between Group A and B except the slightly longer survival in Group A.<br>Although myelodysplasia with hypoplastic marrow is excluded from MDS because of its hypoplastic marrow, they may be essentially the same entity, particularly in respect to hematological disorders preceding the onset of acute leukemia.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 28 (2), 206-212, 1987

    The Japanese Society of Hematology

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