Cytogenetic Study of Essential Thrombocythemia

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  • ABE Rokuo
    The First Department of Internal Medicine, Fukushima Medical College
  • SHIGA Yutaka
    The First Department of Internal Medicine, Fukushima Medical College
  • KIMURA Hideo
    The First Department of Internal Medicine, Fukushima Medical College
  • MATSUDA Shin
    The First Department of Internal Medicine, Fukushima Medical College
  • UCHIDA Tatsumi
    The First Department of Internal Medicine, Fukushima Medical College
  • KARIYONE Shigeo
    The First Department of Internal Medicine, Fukushima Medical College

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Other Title
  • 本態性血小板血症の細胞遺伝学的研究
  • ホンタイセイ ケッショウバン ケッショウ ノ サイボウ イデンガクテキ ケンキ

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Abstract

Cytogenetic studies were performed on the bone marrow (BM) cells obtained from 12 patients with essential thrombocythemia (ET). Two of them had chromosome abnormalities. One patient showed a mosaic of two karyotypes of 46, XY and 46, XY, -15, del (6) (q25), +der (15) t (15; ?) (q26; ?). This abnormal karyotype was observed in half of the checked BM metaphases. The other patient showed only one karyotype of 46, XY, del (20) (q11) in the BM. In both of patients, chromosomal analyses on the cultured peripheral blood cells with phythohemagglutinin (PHA) for 72 hrs were carried out and all metaphases observed were normal male karyotypes. The frequency of polyploid cells was less than 1% in all cases except one with 3.3%. No relationship between cytogenetic findings and clinical manifestations or results of another clinical examinations was observed.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 28 (4), 529-533, 1987

    The Japanese Society of Hematology

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