特発性血小板減少性紫斑病治療中に転移性肝腫瘍による急激な経過をとった放射線治療後子宮頚癌

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タイトル別名
  • Rapidly Progressive Irradiated Cervical Cancer that Metastasized to the Liver During Therapy for Idiopathic Thrombocytopenic Purpura
  • トクハツセイ ケッショウバン ゲンショウセイ シハンビョウ チリョウ チュウ ニ テンイセイ カンシュヨウ

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A 37-year-old woman was given a diagnosis of cervical cancer in August 1994. Because of severe thrombocytopenia, she was given radiation therapy at 50 Gy with great effectiveness. The thrombocytopenia was diagnosed as idiopathic thrombocytopenic purpura. Because the patient refused to undergo a splenectomy operation, she was treated with prednisolone, γ-globulin, and danazol with no effect. In January 1995 she began receiving azathioprine and her platelet count gradually increased. In March, she complained of severe left abdominal pain but abdominal computed tomography (CT) scans showed no abnormal findings. Nonetheless, the patient's lumbago persisted and her liver dysfunction was progressive. Abdominal CT scans performed on April 18 disclosed multiple liver tumors. The patient died on April 28. Autopsy revealed that the cervical cancer was the primary origin of the liver tumors. We concluded that extra precautions should be taken when administering immunosuppressive therapy to patients with a history of malignant diseases.

収録刊行物

  • 臨床血液

    臨床血液 40 (2), 150-152, 1999

    一般社団法人 日本血液学会

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