Tリンパ球がCFU-Eおよび免疫グロブリン産生細胞に対する抑制活性を示したいわゆる重症再生不良性貧血の1例

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タイトル別名
  • A Case of Severe Aplastic Anemia Having T Lymphocytes which Suppressed both CFU-E Colony Formation and Immunoglobulin Production In Vitro
  • Tリンパキュウ ガ CFU-E オヨビ メンエキ グロブリン サンセイ サイボ

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Thia is to report a case of severe aplastic anemia having T lymphocytes in peripheral blood which suppressed both CFU-E colony formation and immunoglobulin production in vitro. A 15 year-old male was referred to our hospital because of progressive pancytopenia which had been noticed for one month. On physical examination severe anemia in conjunctiva was noted. Hematological examination revealed hemoglobin of 5.0g/dl, reticulocyte of 0.7%, platelet count of 1.3 x 104/μl and neutrophils of 476/μl. Bone marrow was hypocellular and 87.2% of nucleated cells were lymphocyte. Ferrokinetic study revealed PID T 1/2 of 320 min. and RIU of 10%. Immunologically, 89.3% of peripheral blood lymphocyte had T cell markers, of which 45.6% were Tγ cells. T cell had a suppressor activity for immunoglobulin producing cells. Bone marrow co-culture studies prior to transfusion revealed that peripheral T cells had a suppressor activity for CFU-E but not CFU-C. He did not respond to treatment and expired 87 days after first visit. In this case, pathogenetic significance of T lymphocytes was uncertain, but it played some role for the clinical course. Furthermore, progressive lymphocytopenia in this patient suggested a derangement in lymphoid stem cell or pluripotent stem cell.

収録刊行物

  • 臨床血液

    臨床血液 22 (3), 386-391, 1981

    一般社団法人 日本血液学会

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