Clinical study of four patients with hematological malignancy treated with allogeneic bone marrow transplantation after conditioning including hyperfractionated total body irradiation.

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  • KUBO Kazuaki
    The Department of Internal Medicine, Branch Hospital, Nagoya Medical School
  • NAITO Kazuyuki
    The Department of Internal Medicine, Branch Hospital, Nagoya Medical School
  • AKAO Yukihiro
    The Department of Internal Medicine, Branch Hospital, Nagoya Medical School
  • HIRAIWA Akikazu
    The Department of Internal Medicine, Branch Hospital, Nagoya Medical School
  • NAOE Tomoki
    The Department of Internal Medicine, Branch Hospital, Nagoya Medical School
  • YAMADA Kazumasa
    The Department of Internal Medicine, Branch Hospital, Nagoya Medical School
  • MATSUNAGA Kayoko
    The Department of Dermatology, Branch Hospital, Nagoya Medical School
  • KOBAYASHI Hidetoshi
    The Department of Radiology, Nagoya Medical School
  • MATSUZAKI Michio
    The 1st Department of Internal Medicine, Yokohama City Medical School

Bibliographic Information

Other Title
  • 過分割全身放射線照射を含めた前処置後に同種骨髄移植を施行した造血器悪性腫よう患者４症例の臨床的検討
  • 過分割全身放射線照射を含めた前処置後に同様骨髄移植を施行した造血器悪性腫瘍患者4症例の臨床的検討
  • カ ブンカツ ゼンシン ホウシャセン ショウシャ オ フクメ タ マエ ショチ

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Abstract

Based on the cytoreductive regimen reported by O'Reilly et al, we transplanted to four patients with hematological malignancy the bone marrow cells harvested from their HLA identical siblings. In our method, they were pretreated with hyperfractionated total body irradiation (120R×11 times) and high dose of cyclophosphamide prior to transplantation. Case 1: 19 year-old, female, ALL. She had a temporal GVHD (Grade I) on day 23, and suffered from interstitial pneumonia (IP) on day 72 that responded well to the steroid therapy. She is now healthy (day 717). Case 2: 15 year-old, female, ALL. She had a mild GVHD on day 20 and IP on day 175 that recovered shortly after treated with steroid. She had an acute nephritis temporarily on day 410, as well. She is now healthy (day 668). Case 3: 39 year-old, female, AML. She suffered from a GVHD (Grade IV) with severe skin eruption, diarrhea and jaundice, which started on day 15. She died of hepatic failure on day 74, for which GVHD was responsible. Case 4: 25 year-old, male, Burkitt Lymphoma. He had a mild GVHD on day 33, which recovered soon with the steroid therapy. On day 150, he suffered from IP to which the steroid therapy was effective. However, IP was recurrent as well as his pneumothorax that happened subsequently. He is now healthy (day 458).

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 28 (1), 40-46, 1987

    The Japanese Society of Hematology

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