Successful treatment with G-CSF and corticosteroid of adult idiopathic autoimmune neutropenia presenting as recurrent enterocolitis

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  • FUJIMI Akihito
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • MATSUNAGA Takuya
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • OHNISHI Rika
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • TAKEMOTO Naofumi
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • TANAKA Ikuta
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • AKIYAMA Takehide
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • SATO Tsutomu
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • MORII Kazuhiro
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • TERUI Takeshi
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • KOGAWA Katsuhisa
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • KATO Junji
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine
  • HIRAYAMA Michiaki
    Department of Internal Medicine, Otaru Ekisaikai Hospital
  • OHMI Naohito
    Department of Internal Medicine, Otaru Ekisaikai Hospital
  • SAKAMAKI Sumio
    Department of Internal Medicine, Higashisapporo Hospital
  • NIITSU Yoshiro
    4th Department of Internal Medicine, Sapporo Medical University School of Medicine

Bibliographic Information

Other Title
  • 反復する感染性腸炎を契機に診断され，G-CSFと副腎皮質ステロイドが著効した成人発症の特発性自己免疫性好中球減少症
  • 症例 反復する感染性腸炎を契機に診断され,G-CSFと副腎皮質ステロイドが著効した成人発症の特発性自己免疫性好中球減少症
  • ショウレイ ハンプク スル カンセンセイ チョウエン オ ケイキ ニ シンダン サレ G CSF ト フクジン ヒシツ ステロイド ガ チョコウシタ セイジン ハッショウ ノ トクハツセイ ジコ メンエキセイ コウ チュウキュウ ゲンショウショウ

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Abstract

A 63-year-old woman had previously been admitted to another hospital due to fever, abdominal pain and diarrhea. She was treated with fasting, antibiotics and G-CSF administration because of the coexistence of neutropenia, and the symptoms improved. However, discontinuation of G-CSF administration resulted in a recurrence of the neutropenia accompanied with enterocolitis. After admission to our hospital, a diagnosis for idiopathic AIN was performed as she tested positive in both granulocyte immunofluorescence and granulocyte agglutination tests. Administration of corticosteroid following G-CSF resulted in a continuous increase in the neutrophil count and the disappearance of anti-neutrophil autoantibodies.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 43 (11), 998-1003, 2002

    The Japanese Society of Hematology

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