Hypereosinophilic syndrome with DIC treated successfully with a combination of high-dose methylprednisolone and cyclosporin A

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  • FUKUTA Akiko
    First Department of Internal Medicine, Gifu University School of Medicine
  • HARA Takeshi
    First Department of Internal Medicine, Gifu University School of Medicine
  • TSURUMI Hisashi
    First Department of Internal Medicine, Gifu University School of Medicine
  • MORIWAKI Hisataka
    First Department of Internal Medicine, Gifu University School of Medicine

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Other Title
  • ステロイドパルス療法にシクロスポリンAの併用が有用であったDIC併発hypereosinophilic syndrome
  • ステロイドパルス リョウホウ ニ シクロスポリン A ノ ヘイヨウ ガ ユウヨウ デ アッタ DIC ヘイハツ hypereosinophilic syndrome

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Description

A 47-year-old man was admitted to our hospital with subcutaneous nodules on the bilateral lower legs and disseminated intravascular coagulation (DIC). Peripheral blood examination revealed leukocytosis with an increase of mature eosinophils, thrombocytopenia and abnormal coagulation. Bone marrow aspiration revealed an increased eosinophil count, and a diagnosis of hypereosinophilic syndrome (HES) was made. Prednisolone (PSL) therapy was not effective. Subsequent methylPSL pulse therapy followed by PSL brought about a transient improvement of the HES and DIC, but after reduction of the PSL, the HES worsened. After addition of cyclosporin A to the PSL, however, the HES improved and did not worsen.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 42 (11), 1145-1147, 2001

    The Japanese Society of Hematology

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