Effective treatment with rituximab in a patient with refractory idiopathic thrombocytopenic purpura
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- TANAI Chiharu
- Division of Hematology, NTT Kanto Medical Center
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- IKI Seiko
- Division of Hematology, NTT Kanto Medical Center
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- NAKAHARA Fumio
- Division of Hematology, NTT Kanto Medical Center
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- IIJIMA Kimiko
- Division of Hematology, NTT Kanto Medical Center
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- USUKI Kensuke
- Division of Hematology, NTT Kanto Medical Center
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- KUWANA Masataka
- Institute for Advanced Medical Research, Keio University School of Medicine
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- URABE Akio
- Division of Hematology, NTT Kanto Medical Center
Bibliographic Information
- Other Title
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- Rituximabが有効であった難治性特発性血小板減少性紫斑病
- 臨床研究 Rituximabが有効であった難治性特発性血小板減少性紫斑病
- リンショウ ケンキュウ Rituximab ガ ユウコウ デ アッタ ナンジセイ トクハツセイ ケッショウバン ゲンショウセイ シハンビョウ
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Abstract
A 75-year-old woman had an episode of sudden nasal and oral bleeding. After that, petechiae appeared on her entire body. She received a platelet transfusion, and was referred to our hospital. On admission, the platelet count was as low as 1.2×104/μl, and the PAIgG level was slightly elevated. Bone marrow cellularity was low, with a normal count of megakaryocytes. Anti-glycoprotein IIb/IIIa antibody-secreting B cells in the peripheral blood and platelet-associated anti-glycoprotein IIb/IIIa antibodies were significantly high, and the patient was diagnosed as having idiopathic thrombocytopenic purpura (ITP). She failed to respond to corticosteroids, splenectomy and other therapies, so we administered rituximab, anti-CD20 monoclonal antibody, 375 mg/m2 weekly for four weeks. After the second infusion of rituximab, the platelet count began to increase. The platelet count continued to rise until a peak count (15.0×104/μl) observed after 2 weeks from the fourth infusion, and the response was maintained for 8 more weeks. The levels of anti-glycoprotein IIb/IIIa antibody-secreting B cells and platelet-associated anti-glycoprotein IIb/IIIa antibodies decreased after the administration of rituximab. Rituximab was effective in this case of refractory ITP.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 45 (11), 1181-1186, 2004
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390001205031628672
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- NII Article ID
- 130004500900
- 10014042969
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:DC%2BD2cnjtl2ksQ%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 7167210
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- PubMed
- 15609684
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed