Coagulation Study before Oncet of Disseminated Intravascular Coagulation

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  • WADA Hideo
    The 2nd Department of Internal Medicine, Mie University School of Medicine
  • TAKAGI Mikio
    The 2nd Department of Internal Medicine, Mie University School of Medicine
  • MORI Yoshitaka
    The 2nd Department of Internal Medicine, Mie University School of Medicine
  • DEGUCHI Akira
    The 2nd Department of Internal Medicine, Mie University School of Medicine
  • SUZUKI Hikoji
    The 2nd Department of Internal Medicine, Mie University School of Medicine
  • IWASAKI Eiichi
    The 2nd Department of Internal Medicine, Mie University School of Medicine
  • OHTA Tizuko
    Department of Internal Medicine, Matsusaka Tyuuou Hospital
  • TSUJI Kouta
    Department of Internal Medicine, Yamada Red Cross Hospital
  • KOBAYASHI Thoru
    The 2nd Department of Internal Medicine, Mie University School of Medicine
  • YAMAGUCHI Tetuo
    Department of Internal Medicine, Mastusaka Saiseikai Hospital
  • KATOU Masami
    Department of Internal Medicine, Tyuusei Sougou Hospital
  • DEGUCHI Katsumi
    The 2nd Department of Internal Medicine, Mie University School of Medicine
  • SHIRAKAWA Shigeru
    The 2nd Department of Internal Medicine, Mie University School of Medicine

Bibliographic Information

Other Title
  • 播種性血管内凝固症候群(DIC)準備状態に関する検討
  • ハシュセイ ケッカンナイ ギョウコ ショウコウグン DIC ジュンビ ジョウタ

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Description

We performed blood coagulation studies in 50 patients within a week before onset of disseminated intravascular coagulation (DIC).<br>Since two peaks were observed for the onset, it was suspected that DIC was composed of acute and chronic types. The DIC score before onset was 4.9±1.2 in the non-leukemic group and 2.4±0.8 in the leukemic group.<br>Prekallikrein activity, FDP, fibrinogen and platelet number were frequently abnormal, but PT and antithrombin III weré slightly abnormal in the non-leukemic group.<br>Although the incidence of abnormal finding was lower in the leukemia group than in the non-leukemia group, the data on the leukemia group were similar to those on the non-leukemic group and elevated D-dimer level and decreased platelet count were particularly frequent in the leukemic group. The incidence of abnormal data in all patients was 44±14%.<br>Abnormalities of blood coagulation were observed within a week before the onset of DIC, and prekallikrein activity, platelet number, FDP and D-dimer might be useful for diagnosis of Pre-DIC state.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 29 (11), 2011-2017, 1988

    The Japanese Society of Hematology

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