Gastric relapse of stage I ocular adnexal mucosa-associated lymphoid tissue lymphoma

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  • SATO Tsutomu
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • TAKIMOTO Rishu
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • IYAMA Satoshi
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • ONO Kaoru
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • TANAKA Shingo
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • ARAKI Naoko
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • NISHIIE Kiwami
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • MURASE Kazuyuki
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • SATO Yasushi
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • KOBUNE Masayoshi
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • MATSUNAGA Takuya
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • KATO Junji
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • NIITSU Yoshiro
    Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine

Bibliographic Information

Other Title
  • 胃に再発したstage I 涙腺原発 mucosa-associated lymphoid tissue lymphoma
  • 症例報告 胃に再発したstage 1涙腺原発mucosa-associated lymphoid tissue lymphoma
  • ショウレイ ホウコク イ ニ サイハツ シタ stage 1 ルイセン ゲンパツ mucosa associated lymphoid tissue lymphoma

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Abstract

A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against Helicobacter pylori was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin α4β7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin α4β7.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 48 (1), 56-60, 2007

    The Japanese Society of Hematology

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