Epstein-Barr virus related B-cell lymphoproliferative disorder complicated with bone marrow fibrosis, which was successfully treated with 2 courses of CHOP regimen

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  • HAGIHARA Masao
    Department of Internal Medicine, Ebina General Hopital Department of Hematology and Rheumatology, Tokai University
  • WATANABE Shigeki
    Department of Internal Medicine, Ebina General Hopital Department of Hematology and Rheumatology, Tokai University
  • SUYAMA Takahiro
    Department of Internal Medicine, Ebina General Hopital
  • SATO Koji
    Department of Internal Medicine, Ebina General Hopital Department of Hematology and Rheumatology, Tokai University

Bibliographic Information

Other Title
  • 骨髄線維症を伴い，2クールのCHOP療法が奏効したEBウイルス関連性Bリンパ球増殖性疾患
  • 症例 骨髄線維症を伴い,2クールのCHOP療法が奏効したEBウイルス関連性Bリンパ球増殖性疾患
  • ショウレイ コツズイ センイショウ オ トモナイ 2クール ノ CHOP リョウホウ ガ ソウコウ シタ EB ウイルス カンレンセイ Bリンパキュウ ゾウショクセイ シッカン

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Abstract

A 68-year-old man was referred to our hospital in August 2003 with a high fever, a prominent inflammatory reaction in blood test and also bicytopenia (anemia and thrombocytopenia) with marked hepatosplenomegaly. He was temporarily diagnosed as having malignant lymphoma considering the elevated levels of LDH and soluble interleukin-2 receptor, following which treatment with the CHOP regimen was started. Thereafter, based on the pathological findings from a bone marrow biopsy and a quite high viral load revealed by real-time PCR analysis, the diagnosis was changed to Epstein-Barr virus (EBV) related B-lymphoproliferative disorder (B-LPD) complicated with reticulin fibrosis. A total of 2 courses of the CHOP regimen together with anti-viral reagents almost resolved the clinical symptoms and abnormal findings of laboratory tests. This unique case was considered to be “a senile EBV positive B-LPD” complicated with a secondary myelofibrosis, a category of the disorder which has recently been proposed by Shigeo Nakamura at the Aichi Cancer Center.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 46 (10), 1129-1135, 2005

    The Japanese Society of Hematology

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