Vinca-Alkaloid Slow Infusion Therapy in Refractory Idiopathic Thrombocytopenic Purpura
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- ENDOH Nobuyuki
- 2nd Department of Internal Medicine, Chiba University School of Medicine
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- WONG Pakming
- 2nd Department of Internal Medicine, Chiba University School of Medicine
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- WAKITA Hisashi
- 2nd Department of Internal Medicine, Chiba University School of Medicine
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- NAKAMURA Hirotoshi
- 2nd Department of Internal Medicine, Chiba University School of Medicine
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- SUGIURA Yuri
- 2nd Department of Internal Medicine, Chiba University School of Medicine
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- ASAI Takayoshi
- 2nd Department of Internal Medicine, Chiba University School of Medicine
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- ITOH Kuniaki
- 2nd Department of Internal Medicine, Chiba University School of Medicine
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- YOSHIDA Sho
- 2nd Department of Internal Medicine, Chiba University School of Medicine
Bibliographic Information
- Other Title
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- 難治性ITPに対するVinca-Alkaloid緩速静注療法の試み
- ナンジセイ ITP ニ タイスル Vinca Alkaloid カンソク ジョ
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Abstract
Vinca-alcaloid (V-A) was given in slow infusion to six adult patients with refractory idiopathic thrombocytopenic purpura (ITP), including 5 were unresponsive to glucocorticoids, and one who was unresponsive to danazol. Vincristine, 0.02 mg/kg or vinblastine 0.1 mg/kg, was dissolved in 500 ml of isotonic saline and infused intravenouslty over 6 hours.<br>The mean platelet count of the patients on study was 2.18±1.3 (×104/mm3), which rose to 6.8±3.7 (×104/mm3) to 7.8±4.4 (×104/mm3), to 11.2±6.6 (×104/mm3) and to 14.9±5.1 (×104/mm3), 1, 4, 8 and 15 weeks after the begnining of therapy, respectively. Side effects, including mild neuropathy, constipation, alopecia, and leukopenia were common on V-A slow infusion, but were decreased by the reduction of dose of V-A, except severe neuropathy in one patient who needed the cessation of therapy.<br>These findings indicated that Vinca-alkaloid slow infusion therapy is effective and tolerable to the patients with refractory ITP.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 28 (2), 194-198, 1987
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390001205032581376
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- NII Article ID
- 130004499117
- 40003771971
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:BiiC1MbislM%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 3123767
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- PubMed
- 3573337
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed