リネゾリド長期投与による鉄芽球性貧血

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  • Sideroblastic anemia after prolonged linezolid therapy
  • リネゾリド チョウキ トウヨ ニ ヨル テツ ガキュウセイ ヒンケツ

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抄録

Linezolid is an effective and well-tolerated antibiotic for the treatment of infections caused by Gram-positive pathogens. Some reports have shown that linezolid treatment for more than 2 weeks has been associated with reversible bone marrow suppression, especially thrombocytopenia and anemia. We encountered a case of sideroblastic anemia following prolonged linezolid therapy in a laryngeal cancer patient. He received linezolid therapy for multiple abscesses due to MRSA. Before treatment, the Hb level was 12.5 g/dl and then slowly decreased to 5.9 g/dl for 2 months during treatment. Ringed sideroblasts were detected in the bone marrow. Linezolid was discontinued and the Hb level was slowly increased. This case was considered to reflect a rare complication of linezolid therapy.

収録刊行物

  • 臨床血液

    臨床血液 49 (11), 1566-1568, 2008

    一般社団法人 日本血液学会

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