A Case of Acute Myeloblastic Leukemia with Auer's Bodies in Mature Neutrophils

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  • 成熟好中球にAuer小体を認めた急性骨髄性白血病の1症例

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Abstract

A 14-year-old male was admitted on June 3, 1982 because of pyrexia and nosebleed. Physical examination revealed neither lymphadenopathy nor hepatosplenomegaly.<br>Laboratory examination showed RBC 137×104/cmm, hemoglobin 4.9 g/dl, Ht 13.5%, platelets 1.1×104/cmm, and WBC 6,600/cmm with 38.5% myeloblasts and 3% promyelocytes. Auer's bodies were observed in immature leukemic cells and in mature neutrophils with pseudo-Pelger-Huët's anomaly. Neutrophil alkaline phosphatase (NAP) activity was low. A sternal marrow aspiration disclosed hypercellular marrow (nucleated cell count, 272,000/cmm) with 64.9% myeloblasts and 1.9% promyelocytes. A diagnosis of acute myeloblastic leukemia (M2 in FAB classification) was made. A complete remission was obtained by combination chemotherapy with daunomycin, Ara-C, BH-AC and prednisolone. Auer's bodies in both blast cells and mature neutrophils disappeared and NAP activity rose to normal level after complete remission. In this case, neutrophils with Auer's bodies might orignate from immature leukemic cells. It is suggested that leukemic cells differentiate to mature neutrophils in some case of acute myeloid leukemia.

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  • Rinsho Ketsueki

    Rinsho Ketsueki 25 (3), 372-376, 1984

    The Japanese Society of Hematology

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