鼻中隔腫瘤で発症し，Co照射及びOK-432の併用療法により長期生存し得たT Cell Lymphomaの一症例

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タイトル別名
  • A Case of T Cell Lymphoma Arising from the Nasal Septum with a Long Survival Time by the Combined Therapy with Irradiation and Immunopotenciator
  • 鼻中隔腫瘤で発症し,Co照射及びOK-432の併用療法により長期生存し得たT Cell Lymphomaの1症例
  • ビチュウカク シュリュウ デ ハッショウシ Co ショウシャ オヨビ OK 4

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This paper presents a case of T-cell lymphoma with a long survival achieved by radiation and immunochemotherapy.<br>A 46 year old male, a non-native of Kyushu district, was admitted to our service for the further evaluation and treatment of subcutaneous tumor of r. shoulder and l. arm on January 1979. Two years prior to admission the patient was diagnosed as malignant lymphoma from the histological findings of dissected nasal septal tumor, which was treated by irradiation therapy alone. A tumor of the r. inguinal region was extripated for further evaluation and was diagnosed as poorly differentiated malignant lymphoma. These tumor cells formed rosette with sheep erythrocytes. Bone marrow aspiration revealed hypocellularity without tumor cells and he was treated by prednisolone alone with poor response and additional local administration of OK-432 was started into the tumor which became soften in consistency and decreased in size. Positive direct Coomb's test and antiplatelet antibody were detected in short time of thrombocytopenia, and the increased administration of prednisolone improved the platelet counts. In spite of immunochemotherapy including prednisolone, Bleomycin, oil-Bleo and OK-432, the tumor size was increased and symptom was aggravated and expired on March 1979 due to shock induced by oil-Bleo injection.<br>Through the clinical evaluation of this patient, it is emphasized that 28 months long survival was achieved responding to the treatment with irradiation and local OK-432 administration. This case of T-cell lymphoma suggested the effectiveness of the combined therapy with irradiation and immunopotenciator.

収録刊行物

  • 臨床血液

    臨床血液 21 (12), 1892-1897, 1980

    一般社団法人 日本血液学会

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