A case of patient with complete remission from atypical aplastic anemia by betamethasone therapy, whose peripheral lymphocytes suppressed granulocytic colony formation (CFU-C) of normal bone marrow cells

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  • 患者リンパ球にCFU-C抑制作用を認めbetamethasoneが著効を呈した非定型的aplastic anemiaの一例
  • 患者リンパ球にCFU-C抑制作用を認め,betamethasoneが著効を呈した非定型的aplastic anemiaの1例
  • カンジャ リンパキュウ ニ CFU-C ヨクセイ サヨウ オ ミトメ beta

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Abstract

Up to the present, the pathogenesis of aplastic anemia has been discussed by many investigators, but it still remains in dispute. Lately in some cases of aplastic anemia the suppression to bone marrow stem cells through immunological mechanism was suspected for the ca use of this disease.<br>In the present report, we describe a young male patient of atypical aplastic anemia, whose peripheral lymphocytes suppressed a colony forming unit (CFU-C) of normal marrow cells.<br>Although the anabolic steroid was proved to be ineffective, complete remission was brought by the treatment with a high dose of betamethasone.<br>It was therefore assumed that in this patient the circulating lymphocyte was playing a pathognomonic role for aplastic anemia by their suppressive activity on the proliferation of bone marrow cells.

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  • Rinsho Ketsueki

    Rinsho Ketsueki 23 (3), 385-391, 1982

    The Japanese Society of Hematology

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