再生不良性貧血における輸血の現況と問題点

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タイトル別名
  • Problems in Blood Transfusion in Patients with Aplastic Anemia
  • 再生不良性貧血における輸血の現状と問題点
  • サイセイ フリョウセイ ヒンケツ ニ オケル ユケツ ノ ゲンジョウ ト モン

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In order to assess the value of blood transfusions in the management of aplastic anemia patients, the amount and types of blood transfused were studied in 102 patients seen between 1958 and 1980. Transfusion requirement was inversely related to the blood hemoglobin level. The transfusion requirement also showed a close relationship to responsiveness to the androgen therapy. Thus, the median amount of blood transfused was 2,200ml in androgen-responding cases, and 8,800ml in androgen-nonresponding cases. A comparable amount of blood was transfused for the first 3 months in both groups. However, androgen responding groups required progressively lesser amount of blood with time after initiation of treatment, while the transfusion requirement showed a steady increase in androgen-nonresponding groups. Retrospective analysis of the blood transfusions in chronic aplastic anemia patients between 1958 and 1980 revealed that the average amount of blood transfused per patient per year decreased to nearly half during this period of time. Leukocyte-poor blood or washed red cells were the types of blood preferentially used in recent years. Platelet or granulocyte transfusions were employed only in acute cases and/or cases with severe complications. The significance of androgen therapy has been discussed in relation to the evaluation of transfusion requirement in aplastic anemia.

収録刊行物

  • 臨床血液

    臨床血液 23 (3), 325-331, 1982

    一般社団法人 日本血液学会

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