A Case of High Phosphatidylcholine Hemolytic Anemia

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  • UCHIDA Tatsumi
    The First Department of Internal Medicine, Fukushima Medical College
  • KIMURA Hideo
    The First Department of Internal Medicine, Fukushima Medical College
  • SAKAI Kazuyoshi
    The First Department of Internal Medicine, Fukushima Medical College
  • IGARASHI Tadayuki
    The First Department of Internal Medicine, Fukushima Medical College
  • MATSUDA Shin
    The First Department of Internal Medicine, Fukushima Medical College
  • KARIYONE Shigeo
    The First Department of Internal Medicine, Fukushima Medical College
  • MAEZAWA Masaji
    The First Department of Internal Medicine, Jichi Medical College
  • TAKAKU Fumimaro
    The First Department of Internal Medicine, Jichi Medical College

Bibliographic Information

Other Title
  • 赤血球高phosphatidylcholine溶血性貧血の1例
  • セッケッキュウ コウ phosphatidylcholine ヨウケツセイ ヒ

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Abstract

A case of nonspherocytic hemolytic anemia associated with abnormalities in membrane lipids was described. The 19-year-old boy was consulted because of jaundice and left hypochondralgia. Splenectomy had been performed two years before. On admission, hemolytic anemia was evident, having 12.3g/dl of hemoglobin, 208‰ of reticulocytes, indirect bilirubin of 5.5mg/dl and the presence of target red cells in peripheral blood smears. The patient's red cells had an absolute increase in erythrocyte phosphatidylcholine. There was no evidence for abnormalities in glycolytic enzymes, hemoglobin analysis, liver function test or plasma lipids. Osmotic fragility was decreased, Coombs' test was negative and 51Cr labeled red cell survival was 6.2 days. It was concluded that the hemolytic anemia was due to an intrinsic red cell defect, which was elevated phosphatidylcholine in red cell membrane lipids. There are only two reports of high phosphatidylcholine hemolytic anemia in the world.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 23 (2), 193-198, 1982

    The Japanese Society of Hematology

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