Transient Remission of a Non-haemophilic Patient with Acquired Factor VIII Inhibitor Treated with a Single Infusion of Factor VIII and cyclophosphamide

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  • KUTSUZAWA Tomoko
    The Fourth Department of Internal Medicine, School of Medicine, Tokai University
  • NOZAKI Hiroyuki
    The Fourth Department of Internal Medicine, School of Medicine, Tokai University
  • ICHIKAWA Yukinobu
    The Fourth Department of Internal Medicine, School of Medicine, Tokai University
  • NAGAO Tadami
    The Fourth Department of Internal Medicine, School of Medicine, Tokai University
  • ARIMORI Shigeru
    The Fourth Department of Internal Medicine, School of Medicine, Tokai University

Bibliographic Information

Other Title
  • 第VIII因子阻害物質陽性非血友病者に第VIII因子大量輸注とcyclophosphamide大量1回投与で一時的寛解に達しえた1例
  • 第8因子阻害物質陽性非血友病者に第8因子大量輸注とcyclophosphamide大量1回投与で一時的寛解に達しえた1例
  • ダイ 8 インシ ソガイ ブッシツ ヨウセイ ヒ ケツユウ ビョウシャ ニ ダ

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Abstract

A 54-year-old male was admitted to the Tokai University Hospital because of intramuscular and subcutaneous hemorrhage on July 15, 1980.<br>Partial gastrectomy had been performed on him because of gastric ulcer in June, 1977 and stomal ulcer was re-operated in December, 1979, when he received blood transfusion, sulbenicillin and penicillin G.<br>Physical examination revealed ecchymoses over the right arm and the left hand. Coagulation studies showed prolonged partial thromboplastin time and decreased factor VIII activity (1.8%). Inhibitor to factor VIII was demonstrated by 48 Bethesda units. Gel filtration of the patient plasma on Sephadex G-200 revealed the inhibitor activity was present in the second protein peak.<br>He was initially treated with prednisolone and cyclophosphamide without any improvement of factor VIII activity. Then a large dose of factor VIII (5,000 U) and a single infusion of cyclophosphamide (500 mg) were given, which resulted in disappearance of the inhibitor and improvement of the coagulation profiles, although he developed acute hepatitis and the concentration of factor VIII inhibitor increased again 6 weeks later.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 23 (2), 173-179, 1982

    The Japanese Society of Hematology

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