メルファラン大量投与におけるクライオテラピーの有効性の検討

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  • Cryotherapy is useful and safe in the prevention of oral mucositis after high-dose melphalan (L-PAM)
  • メルファラン タイリョウ トウヨ ニ オケル クライオテラピー ノ ユウコウセイ ノ ケントウ

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We prospectively assessed the effectiveness of cryotherapy after high-dose L-PAM to prevent oral mucositis. Cryotherapy with ice tips was commenced 15 minutes before L-PAM administration, and continued until the end of administration. Twenty-six patients were enrolled in this study. Thirteen patients with myeloma were treated with 200 mg/m2 L-PAM followed by autologous peripheral blood stem cell transplantation, and 13 patients (4 AML, 4 MDS, 2 ALL, 2 lymphoma and 1 CML) were treated with 140 mg/m2 L-PAM followed by allogeneic stem cell transplantation. Grade 1 mucositis occurred in four of 13 patients (31%) with 200 mg/m2 L-PAM, and 2 of 13 patients (16%) with 140 mg/m2 L-PAM. Only one patient had grade 2 mucositis, and no grade 3 mucositis were observed. The procedure was well tolerated in all patients. These data suggest that cryotherapy is effective to minimize L-PAM-induced oral mucositis.

収録刊行物

  • 臨床血液

    臨床血液 47 (11), 1469-1471, 2006

    一般社団法人 日本血液学会

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