Hematological Studies on Thyrotoxic Patients

SHIRAKURA Takuo, MAEKAWA Tadashi, YAMATO Kensho

doi:10.11406/rinketsu.12.551

Hematological investigations, including erythrokinetic analysis, were carried out on 16 female and 3 male patients with hyperthyroidism, admitted to our department during the last 7 years. Results obtained were as follows: 1. Eleven out of these thyrotoxic patients, were slightly or moderately anemic, and in 8 cases with anemia their MCH level was less than 25 μμg. 2. Serum iron levels were lowered in 6 cases among 10 anemic patients, and UIBC were increased in all of 5 cases subjected to determination. Ferrokinetic study, carried out in 7 anemic cases, revealed a shortened PID with norma 1% RCU. Although values of both PIT and RCIT were normal or slightly high in all these cases, mean values of daily Hb production calculated from the data obtained erythrocyte survival study were decreased in 6 cases with anemia under hematologically steady state. 3. Apparent half survival time of erythrocytes in thyrotoxic patients ranged from 17.4 to 31.4 days. 4. Except for a few cases, iron treatment was required in most of cases with hypochromic anemia after the antithyroid therapy. In some of these cases, oral iron preparations given during hyperthyroid state could not raise their Hb level. From these results it is concluded that anemia was frequently complicated with thyrotoxicosis and that the main cause of anemia seemed to be iron deficiency. Peroral iron treatment was effective only after improvement of thyrotoxicosis in many of anemic patients with iron deficiency. It is suggested, however, that other types of anemia than iron deficiency were occasionally observed in thyrotoxic patients. Further study is required to elucidate the cause of these types of anemia.

Hematological Studies on Thyrotoxic Patients

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