小児の悪性組織球症4例に対する交換輸血と多剤併用療法による治療経験

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タイトル別名
  • Exchange Transfusion and Combination Chemotherapy in the Treatment of 4 Cases of Childhood Malignant Histiocytosis
  • ショウニ ノ アクセイ ソシキキュウショウ 4レイ ニ タイスル コウカン ユ

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抄録

Four patients with malignant histiocytosis were initially treated with exchange transfusion (150-200 ml/kg×1-2) and ACOP (adriamycin/cyclophosphamide/vincristine/prednisolone). On admission, all the patients, 3 girls and 1 boy, with the median age of 2 yrs 7 mos., ranging from 10 mos. to 14 yrs-old, showed septic-type fever and had DIC syndrome, associated with disturbance of consiciousness. Two of them also suffered from renal failure.<br>In all 4 cases, after exchange transfusion, abnormal high serum LDH was markedly decreased, and total protein and cholesterol values were normalized, and in two cases, consciousness became clear. Although two patients died on Day 16 and Day 19, the other two recovered completely and maintained complete remission with further treatment until relapse and subsequent death.

収録刊行物

  • 臨床血液

    臨床血液 28 (6), 845-851, 1987

    一般社団法人 日本血液学会

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