Mechanisms of drug resistance in acute lymphoblastic leukemia

DOI Web Site PubMed

Bibliographic Information

Other Title
  • 急性リンパ性白血病の薬剤耐性機序
  • キュウセイ リンパセイ ハッケツビョウ ノ ヤクザイ タイセイ キジョ

Search this article

Abstract

<p>Outcomes of patients with acute lymphoblastic leukemia (ALL) have improved dramatically with conventional chemotherapy consisting of multiple agents. However, considering the major impact of tyrosine kinase inhibitors in the treatment of Philadelphia chromosome-positive ALL, sensitivities to each chemotherapeutic agent must be appreciated in individual cases to further improve therapeutic outcomes of ALL patients. Recent advances in genome-wide association and comprehensive genetic mutation studies with next-generation sequencing enable the involvement of single nucleotide polymorphisms and acquired genetic mutations in the drug resistance of ALL to be evaluated. Herein, we overview recent findings regarding the mechanisms of drug resistance in ALL. Our observations in a large panel of ALL cell lines are also presented.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 57 (10), 2022-2028, 2016

    The Japanese Society of Hematology

Keywords

Details 詳細情報について

Report a problem

Back to top