-
- ASAKURA Hidesaku
- Department of Internal Medicine (III), Kanazawa University School of Medicine
Bibliographic Information
- Other Title
-
- DICの病型分類:臨床と動物モデルの両面から
- DIC ノ ビョウガタ ブンルイ : リンショウ ト ドウブツ モデル ノ リョウメン カラ
Search this article
Abstract
Disseminated intravascular coagulation (DIC) is a pathological state in which varying degrees of fibrinolytic activation are seen simultaneously as systemic, persistent, and marked coagulation activation in the presence of an underlying disease. Suppressed-fibrinolytic-type DIC usually develops in patients with sepsis. Coagulation activation is severe, while fibrinolytic activation is mild. Enhanced-fibrinolytic-type DIC usually occurs with acute promyelocytic leukemia (APL). Both coagulation activation and fibrinolytic activation are severe in affected patients. Balanced-fibrinolytic-type DIC is usually seen in patients with solid tumors, and has a pathogenesis intermediate between those of the two aforementioned types. In animal DIC models, lipopolysaccharide (LPS)-induced forms of DIC are similar to suppressed-fibrinolytic-type DIC, whereas models of tissue factor (TF)-induced DIC have features similar to those of enhanced-fibrinolytic/balanced-fibrinolytic DIC. We are moving in the direction of more appropriate selection of treatment based on DIC type.
Journal
-
- Rinsho Ketsueki
-
Rinsho Ketsueki 57 (4), 397-404, 2016
The Japanese Society of Hematology
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001205034545152
-
- NII Article ID
- 130005150505
-
- NII Book ID
- AN00252940
-
- ISSN
- 18820824
- 04851439
-
- NDL BIB ID
- 027320804
-
- PubMed
- 27169441
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- PubMed
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed