Hepatic arterial infusion of liposomal amphotericin B for multiple fungal abscesses in the liver of a patient with chronic granulomatous disease

DOI Web Site 14 References
  • OGURA Taemi
    Department of Pediatrics, Graduate School of Biomedical Sciences, Hiroshima University
  • KAJIUME Teruyuki
    Department of Pediatrics, Graduate School of Biomedical Sciences, Hiroshima University
  • SERA Yasuhiko
    Department of Pediatrics, Graduate School of Biomedical Sciences, Hiroshima University
  • KAWAGUCHI Hiroshi
    Department of Pediatrics, Graduate School of Biomedical Sciences, Hiroshima University
  • KOBATAKE Makito
    Department of Pediatrics, Graduate School of Biomedical Sciences, Hiroshima University
  • OKAMOTO Noriaki
    Department of Pediatrics, Hyogo College of Medicine
  • OHTSUKA Yoshitoshi
    Department of Pediatrics, Hyogo College of Medicine
  • MATSUMOTO Kana
    Department of Clinical Pharmacy, Doshisha Women's College of Liberal Arts
  • MORITA Kunihiko
    Department of Clinical Pharmacy, Doshisha Women's College of Liberal Arts
  • KOBAYASHI Tsuyoshi
    Department of Surgery II, Graduate School of Biomedical Sciences, Hiroshima University
  • OHDAN Hideki
    Department of Surgery II, Graduate School of Biomedical Sciences, Hiroshima University
  • KOBAYASHI Masao
    Department of Pediatrics, Graduate School of Biomedical Sciences, Hiroshima University

Bibliographic Information

Other Title
  • 慢性肉芽腫症患者に合併した多発真菌性肝膿瘍に対するLiposomal Amphotericin Bの肝動注療法
  • 症例報告 慢性肉芽腫症患者に合併した多発真菌性肝膿瘍に対するLiposomal Amphotericin Bの肝動注療法
  • ショウレイ ホウコク マンセイ ニクゲシュショウ カンジャ ニ ガッペイ シタ タハツ シンキンセイ カン ノウヨウ ニ タイスル Liposomal Amphotericin B ノ カンドウ チュウ リョウホウ

Search this article

Abstract

A 26-year-old man with chronic granulomatous disease complicated by multiple liver abscess was admitted to our hospital for hepatic resection and allogeneic bone marrow transplantation (BMT) from an HLA-matched sibling. We diagnosed the patient with Aspergillus liver abscesses based on computed tomographic findings, elevated serum levels of β-D-glucan, positive test for galactomannan antigen, and the findings of laboratory cultures. Since the liver abscess could not be treated by drainage and administration of antifungals, we resected the posterior segments of the liver, which contained the abscess (S1, S6). However, abscess recurred in the remaining part of the liver 1 month later. The patient received allogeneic BMT from an HLA-matched sibling. During BMT, we continuously administered liposomal amphotericin B (L-AMB) via the hepatic artery (25 mg/day) to treat the liver abscess. There were no adverse effects during hepatic arterial infusion of L-AMB, and the liver abscess disappeared after BMT. These results suggest that hepatic arterial infusion of L-AMB is effective in treating fungal abscess in the liver.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 51 (5), 345-348, 2010

    The Japanese Society of Hematology

References(14)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top