Acute-onset eosinophilic leukemia associated with tumor lysis syndrome after imatinib and steroid pulse therapy

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  • NEMOTO Tomoe
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • SAITO Yuriko
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • TOKUHIRA Michihide
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • TOMIKAWA Atsushi
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • SAGAWA Morihiko
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • HABA Yuichiro
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • HANZAWA Kyoko
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • SEKIGUCHI Yasunobu
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • WATANABE Reiko
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • TAMARU Jun-ichi
    Department of Pathology, Saitama Medical Center, Saitama Medical University
  • ITOYAMA Shinji
    Department of Pathology, Saitama Medical Center, Saitama Medical University
  • MORI Shigehisa
    Department of Hematology, Saitama Medical Center, Saitama Medical University
  • KIZAKI Masahiro
    Department of Hematology, Saitama Medical Center, Saitama Medical University

Bibliographic Information

Other Title
  • 芽球様好酸球増多を伴って，急激な経過を辿りイマチニブとステロイドパルスによる腫瘍崩壊症候群を呈した好酸球性白血病
  • 症例報告 第162回日本血液学会例会:千葉滋例会長 推薦演題 芽球様好酸球増多を伴って,急激な経過を辿りイマチニブとステロイドパルスによる腫瘍崩壊症候群を呈した好酸球性白血病
  • ショウレイ ホウコク ダイ162カイ ニホン ケツエキ ガッカイ レイカイ チバシゲル レイカイチョウ スイセン エンダイ ガキュウ ヨウ コウサンキュウ ゾウ タ オ トモナッテ キュウゲキ ナ ケイカ オ タドリ イマチニブ ト ステロイドパルス ニ ヨル シュヨウ ホウカイ ショウコウグン オ テイシタ コウサンキュウセイ ハッケツビョウ

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Abstract

An 83-year-old woman had been suffering from palpitations and fatigue for a month. An annual screening test revealed an increased WBC count so she was referred to our hospital. CBC showed extremely elevated WBC count (186,300/μl), in which the population of blastic eosinophils was over 90%. The eosinophils expressed CD7/13/33/34/DR, and the karyotype demonstrated 47,XX,+8. The fusion gene of FIP1-LP/PDGFRα in peripheral blood was negative. As plural effusion due to the underlying disease progressively worsened, she was given prednisolone and hydroxyurea, but the effect was limited. Steroid pulse therapy and imatinib (100 mg/day) were administrated. As a result, a prompt response was observed. The WBC count rapidly decreased, but tumor lysis syndrome led to acute renal failure and disseminated intravasucular coagulation appeared. Supportive therapies such as artificial dialysis and transfusions were conducted, but unfortunately she died because of alveolar hemorrhage.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 51 (5), 326-331, 2010

    The Japanese Society of Hematology

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