A case of acute cerebellar ataxia associated with serum anti-NH2 terminal of alpha-enolase (NAE) antibody

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  • Yamamoto Mikie
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
  • Wada-Isoe Kenji
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
  • Yoneda Makoto
    Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui
  • Doi Koji
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
  • Kowa Hisanori
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
  • Nakashima Kenji
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University

Bibliographic Information

Other Title
  • 抗Ｎ末端α－エノラーゼ抗体をみとめた急性小脳失調症の１例
  • コウN マッタン アルファ エノラーゼ コウタイ オ ミトメタ キュウセイ ショウノウ シッチョウショウ ノ 1レイ

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We reported a 61-year-old man who had developed acute cerebellar ataxia in the trunk and the lower limbs. His chemical blood analysis showed very mild hypothyroidism and the presence of serum anti-thyroid peroxidase (TPO) antibody and anti-NH2 terminal of alpha-enolase (NAE) antibody. While cerebellar atrophy was not evident on magnetic resonance imaging (MRI) of the brain, 99mTc-ECD SPECT using the easy Z-score imaging system (e-ZIS) showed decreased regional cerebral blood flow (rCBF) in the vermis of cerebellum. His cerebellar ataxia improved spontaneously within three weeks. The present case is very rare and suggests that anti-NAE autoantibody may be associated with actue cerebellar ataxia.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 50 (8), 581-584, 2010

    Societas Neurologica Japonica

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