IDH mutations activate Hoxa9/Meis1 and hypoxia pathways in acute myeloid leukemia model mice

OGAWARA Yoko, KITABAYASHI Issay

doi:10.11406/rinketsu.56.1045

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IDH変異体は急性骨髄性白血病発症モデルマウスにおいてHoxa9/Meis1経路と低酸素シグナルを活性化する
IDH ヘンイタイワキュウセイコツズイセイハッケツビョウハッショウモデルマウスニオイテ Hoxa9/Meis1 ケイロトテイサンソシグナルオカッセイカスル

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Abstract

Mutations in isocitrate dehydrogenase (IDH) 1 and 2 are frequently observed in acute myeloid leukemia (AML), glioma, and many other cancers. While wild-type IDHs mediate exchanges between isocitrate and α-ketoglutarate (α-KG), mutant IDHs convert α-KG to oncometabolite 2-hydroxyglutarate (2-HG), which causes dysregulation of a set of α-KG-dependent dioxygenases such as TET, histone demethylase and others. Because mutant IDH has no necessary functions in normal cells, inhibitors directed against mutant IDH are not expected to have the side effects as anti-cancer agents. To determine whether mutant IDH enzymes are valid targets for cancer therapy, we created a mouse model of mutant IDH2-dependent AML. By using a combination of AML model mice with cre-loxp, we conditionally deleted mutant IDH2 from AML mice, which resulted in the loss of leukemia stem cells and significantly delayed the progression of AML. These results indicate that mutant IDHs are promising targets for anticancer therapy.

Journal

Rinsho Ketsueki

Rinsho Ketsueki 56 (8), 1045-1052, 2015

The Japanese Society of Hematology

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