A case of isolated hypoglossal nerve palsy with acute lymphoblastic leukemia

  • Kamii Yasuhiro
    Department of Neurology, Katsushika Medical Center, The Jikei University School of Medicine
  • Hashimoto Masaya
    Department of Neurology, Katsushika Medical Center, The Jikei University School of Medicine
  • Suzuki Masahiko
    Department of Neurology, Katsushika Medical Center, The Jikei University School of Medicine
  • Sakimoto Yoshihiro
    Department of Radiology, Katsushika Medical Center, The Jikei University School of Medicine
  • Kawasaki Keiichi
    Department of Neurology, Katsushika Medical Center, The Jikei University School of Medicine
  • Yoshioka Masayuki
    Department of Neurology, Katsushika Medical Center, The Jikei University School of Medicine

Bibliographic Information

Other Title
  • 舌下神経単独麻痺を呈した急性リンパ性白血病の47歳女性例
  • ゼッカ シンケイ タンドク マヒ オ テイシタ キュウセイ リンパセイ ハッケツビョウ ノ 47サイ ジョセイレイ

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Abstract

We report a case of isolated hypoglossal nerve palsy with acute lymphoblastic leukemia. A 47-year-old woman had fever unknown origin during two months. Her tongue bent to the right and cephalalgia developed. She complained unable to speech and swallow. On admission, right isolated hypoglossal nerve palsy presented. Blood examination showed the mild elevation of CRP and soluble IL2 receptor. Examination of cerebrospinal fluid was negative. Gadolinium enhanced magnetic resonance imaging (MRI) of brain showed abnormal intensity on sphenoid bone. 2-[18F] fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) showed abnormal accumulation on sphenoid bone, spleen, the left supraclavicular node, mesenteric lymph node. Blast cells appeared in peripheral blood afterwards. Acute lymphatic leukemia (ALL) was diagnosed by bone marrow biopsy. The central nervous system disorder by ALL tends to the invasion to meninges or cerebrovascular disorder. This is the first case report that isolated hypoglossal nerve paralysis resulted from ALL.

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 53 (3), 243-246, 2013

    Societas Neurologica Japonica

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