Successful treatment with autologous peripheral blood stem cell transplantation for acquired immunodeficiency syndrome (AIDS)-related malignant lymphoma

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  • NAGAI Yuya
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • MORI Minako
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • INOUE Daichi
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • KIMURA Takaharu
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • SHIMOJI Sonoko
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • TOGAMI Katsuhiro
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • TABATA Sumie
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • MATSUSHITA Akiko
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • NAGAI Kenichi
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • IMAI Yukihiro
    Departments of Clinical Pathology, Kobe City Medical Center General Hospital
  • TAKAFUTA Toshiro
    Department of Hematology and Clinical Immunology, Nishi-Kobe Medical Center
  • TAKAHASHI Takayuki
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital

Bibliographic Information

Other Title
  • 自家移植併用大量化学療法を施行し，寛解を維持しているAIDS関連リンパ腫
  • 症例報告 自家移植併用大量化学療法を施行し,寛解を維持しているAIDS関連リンパ腫
  • ショウレイ ホウコク ジカ イショク ヘイヨウ タイリョウ カガク リョウホウ オ シコウ シ カンカイ オ イジ シテ イル AIDS カンレン リンパ シュ

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Description

A 62-year-old man was diagnosed with human immunodeficiency virus (HIV) infection while suffering from recurrent herpes zoster infection. Laboratory examination revealed CD4+ lymphocyte count 16 cells/μl and HIV loading 150,000 copies/ml at presentation. In addition, he had multiple lymph node swelling. Histologic diagnosis of a biopsied lymph node was diffuse, large, B cell-type malignant lymphoma. The karyotype of the lymphoma cells was t(8;14)(q24;q32), which was confirmed by G-banding and fluorescent in situ hybridization. Positron emission tomography (PET)-combined CT scanning revealed systemic extranodal tumors involving the gastrointestinal tract, pancreas, and bone marrow. The clinical stage of the lymphoma was IVB and the international prognosis index was categorized as high. Complete remission (CR) of the lymphoma was obtained after 2 courses of CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) chemotherapy and 4 subsequent courses of rituximab-combined CHOP (R-CHOP). Highly active antiretroviral therapy (HAART) was started at the initiation of CHOP. Because of the poor prognosis of AIDS-related lymphoma, he received autologous peripheral blood stem cell transplantation with the MEAM protocol (ranimustine, etoposide, cytarabine, melphalan) as a conditioning procedure without a severe infectious episode. He remains in CR 24 months after the transplantation.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 50 (11), 1641-1646, 2009

    The Japanese Society of Hematology

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