MALT lymphoma with t (X;14) (p11.2;q32) developing during the course of cutaneous leukocytoclastic angitis
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- UEMURA Yu
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- SAKAI Hirotaka
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- SAIKI Yusuke
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- UCHIDA Akiko
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- SATO Kazuyuki
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- TSURUOKA Yuka
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- YOKOI Satoshi
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- NISHIO Yuji
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- MATSUNAWA Manabu
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- SUZUKI Yoshinori
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- ISOBE Yasushi
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- KATO Masayuki
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- TOMITA Naoto
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- INOUE Yasuyuki
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
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- MIURA Ikuo
- Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
Bibliographic Information
- Other Title
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- 皮膚白血球破砕性血管炎の経過中に発症したt(X;14)(p11.2;q32)を持つMALTリンパ腫
- 症例報告 第6回日本血液学会関東甲信越地方会 優秀演題 皮膚白血球破砕性血管炎の経過中に発症したt(X;14)(p11.2;q32)を持つMALTリンパ腫
- ショウレイ ホウコク ダイ6カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ ユウシュウ エンダイ ヒフ ハッケッキュウ ハサイセイ ケッカンエン ノ ケイカ チュウ ニ ハッショウ シタ t(X;14)(p11.2;q32)オ モツ MALT リンパシュ
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Abstract
<p>A 73-year-old man with left parotid gland swelling over 2 months was referred to our hospital in March 201X. Purpura on the lower legs had been recurrent for >20 years. Biopsy of the parotid gland demonstrated diffuse infiltration of abnormal lymphocytes that were negative for CD10 and positive for CD19, CD20, and κ-chain. The Ki-67 positivity was <10%; lymphoepithelial lesions were observed. The patient was diagnosed with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Chromosome analysis revealed t (X;14) (p11.2;q32), and fluorescence in situ hybridization (FISH) of metaphase spreads showed three signals of the immunoglobulin heavy chain (IGH) gene on the derivative chromosomes X and 14, besides the normal chromosome 14. CT findings of parotid glands were suggestive of Sjogren syndrome, and biopsy of the purpura on the leg demonstrated leukocytoclastic vasculitis. In the literature, only seven patients with lymphoma and t (X;14) translocation have been reported. Of these, five patients had MALT lymphoma, one had nodal marginal zone lymphoma, and one had diffuse large B-cell lymphoma. In all patients, lymphoma evolved from previous autoimmune diseases. It is suggested that MALT lymphoma with the t (X;14) translocation forms a new entity of lymphoma.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 59 (3), 269-274, 2018
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390001205035477248
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- NII Article ID
- 130006627429
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 028975745
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- PubMed
- 29618683
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed