EBV-associated B-cell lymphoproliferative disorder of the elderly successfully treated with autologous peripheral blood stem cell transplantation and locoregional radiotherapy

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  • 自家末梢血幹細胞移植併用大量化学療法および局所放射線療法が奏効した加齢性EBV関連リンパ増殖性疾患
  • 症例報告 自家末梢血幹細胞移植併用大量化学療法および局所放射線療法が奏効した加齢性EBV関連リンパ増殖性疾患
  • ショウレイ ホウコク ジカ マッショウケツ カンサイボウ イショク ヘイヨウ タイリョウ カガク リョウホウ オヨビ キョクショ ホウシャセン リョウホウ ガ ソウコウ シタ カレイセイ EBV カンレン リンパ ゾウショクセイ シッカン

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Abstract

Age-related EBV-associated B-cell lymphoproliferative disorder is a highly aggressive lymphoma, and a standard therapy for this disease has not yet been established. A 58-year-old male was admitted to our hospital because of fever and lymphadenopathy across the whole body. Neck lymph node biopsy showed hemorrhagic and geographic necrosis with Hodgkin-like large cells against a background of small lymphocytes. The large cells were positive for CD30 and EBER. The patient was diagnosed as having age-related EBV-associated B-cell lymphoproliferative disorder. Although there was no response to CHOP therapy, he obtained partial response after 3 courses of DeVIC therapy. Because his lymphoma was highly aggressive and chemotherapy-resistant, he underwent autologous stem cell transplantation with a conditioning regimen including ranimustine, etoposide, cytarabine, and melphalan. After stem cell transplantation and subsequent radiotherapy to the residual lesion, the patient achieved complete remission. This is the first report of successful autologous stem cell transplantation for a patient with age-related EBV-associated B-cell lymphoproliferative disorder.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 52 (3), 129-135, 2011

    The Japanese Society of Hematology

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