Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia
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- GOTO Yoshinori
- Division of Gastroenterological Medicine, Kanazawa University Hospital
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- NISHIMURA Ryosei
- Division of Pediatrics, Kanazawa University Hospital
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- NOHARA Atsushi
- Arteriosclerosis Laboratory, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine
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- MASE Shintaro
- Division of Pediatrics, Kanazawa University Hospital
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- FUJIKI Toshihiro
- Division of Pediatrics, Kanazawa University Hospital
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- IRABU Hitoshi
- Division of Pediatrics, Kanazawa University Hospital
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- KURODA Rie
- Division of Pediatrics, Kanazawa University Hospital
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- ARAKI Raita
- Division of Pediatrics, Kanazawa University Hospital
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- IKAWA Yasuhiro
- Division of Pediatrics, Kanazawa University Hospital
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- MAEBA Hideaki
- Division of Pediatrics, Kanazawa University Hospital
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- YACHIE Akihiro
- Division of Pediatrics, Kanazawa University Hospital
Bibliographic Information
- Other Title
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- 小児急性リンパ性白血病患者のL-asparaginase関連膵炎において重度脂質異常の関与は軽微である
- 症例報告 小児急性リンパ性白血病患者のL-asparaginase関連膵炎において重度脂質異常の関与は軽微である
- ショウレイ ホウコク ショウニ キュウセイ リンパセイ ハッケツビョウ カンジャ ノ L-asparaginase カンレンスイエン ニ オイテ ジュウド シシツ イジョウ ノ カンヨ ワ ケイビ デ アル
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Abstract
<p>A 10-year-old girl developed L-asparaginase (ASP)-associated pancreatitis during chemotherapy for acute lymphocytic leukemia. Her symptoms showed alleviation with continuous regional arterial infusion of protease inhibitor and systemic somatostatin analog therapy. She had intermittent and marked hypertriglyceridemia, an initial trigger for pancreatitis, probably as a side effect of ASP and steroids. However, we considered the pancreatitis to have developed mainly because of factors other than hypertriglyceridemia as lipoprotein analysis confirmed chylomicron levels to be nearly undetectable. Extremely large chylomicrons contribute directly to the onset of pancreatitis by causing blockage of small vessels. Although it is necessary to examine patients for dyslipidemia developing as a side effect of ASP, therapeutic intervention for hypertriglyceridemia is not considered to prevent the onset of ASP-associated pancreatitis.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 57 (8), 994-998, 2016
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390001205035544832
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- NII Article ID
- 130006882249
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 027629845
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- PubMed
- 27599414
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed