ASLO高値を示したIgA myelomaの1例

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書誌事項

タイトル別名
  • IgA Myeloma with Antistreptolysin-O Activity
  • ASLO タカネ オ シメシタ IgA myeloma ノ 1レイ

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抄録

It has been considered that M-protein has no antibody activities. However, since Badin et al. have reported the first case of M-component with anti-streptolysin-O (ASLO) activity, a number of M-components exhibiting various antibody activities have been documented.<br>The immunoglobulin of all the reported cases so far was confined to IgG, and it was found that the antibody activity located on the Fab fragment. The present paper deals with the first case of IgA myeloma with ASLO activity.<br>In this case, it was proved that ASLO activity was present in the fractions corresponding to M-component in agar gel electrophoresis. Because of technical complexity in separating and refining the IgA, the pattern of ASLO activity detected by Rantz-Randall's method in each fractional eluate from electrophoresis of the patients sera was compared to that of IgA concentration in the corresponding fraction. As the result, peak location of IgA concentration coincided with that of ASLO activity.<br>The problem is whether ASLO activity in M-component represents a true antibody activity. In the present case ASLO activity was of abnormally high titer in the Rantz-Randall's method, but it was normal in the passive hemagglutination method. Moreover, we failed to demonstrate that ASLO activity represents true antibody itself, that is, serum of our case did not show precipitation reaction with SLO and not inhibit precipitation reaction between SLO and serum of patient with streptococcus infection.

収録刊行物

  • 臨床血液

    臨床血液 17 (12), 1295-1301, 1976

    一般社団法人 日本血液学会

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