Primary neurolymphomatosis of the cervical nerve root

  • MIKI Miyuki
    Department of Hematology and Immunology, Kanazawa Medical University
  • MASAKI Yasufumi
    Department of Hematology and Immunology, Kanazawa Medical University
  • NAKAMURA Takuji
    Department of Hematology and Immunology, Kanazawa Medical University
  • IWAO Haruka
    Department of Hematology and Immunology, Kanazawa Medical University
  • NAKAJIMA Akio
    Department of Hematology and Immunology, Kanazawa Medical University
  • SAKAI Tomoyuki
    Department of Hematology and Immunology, Kanazawa Medical University
  • SAWAKI Toshioki
    Department of Hematology and Immunology, Kanazawa Medical University
  • KAWANAMI Takafumi
    Department of Hematology and Immunology, Kanazawa Medical University
  • KAITO Muichi
    Department of Neurology, Kanazawa Medical University
  • KUROSE Nozomu
    Department of Pathology and Laboratory Medicine, Kanazawa Medical University
  • FUJITA Yoshimasa
    Department of Hematology and Immunology, Kanazawa Medical University
  • TANAKA Masao
    Department of Hematology and Immunology, Kanazawa Medical University
  • FUKUSHIMA Toshihiro
    Department of Hematology and Immunology, Kanazawa Medical University
  • HIROSE Yuko
    Department of Hematology and Immunology, Kanazawa Medical University
  • UMEHARA Hisanori
    Department of Hematology and Immunology, Kanazawa Medical University

Bibliographic Information

Other Title
  • 頸髄神経根原発のneurolymphomatosis
  • 症例報告 頸髄神経根原発のneurolymphomatosis
  • ショウレイ ホウコク ケイズイシンケイ コンゲンパツ ノ neurolymphomatosis

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Abstract

A 74-year-old woman was admitted with muscle weakness and sharp pain in her upper limbs. On 18FDG-PET, abnormal accumulation was noted on both sides of the brachial plexus at the cervical spinal cord. A diagnosis of primary peripheral nerve neurolymphomatosis was made based on biopsy of the third cervical nerve. Following R-CHOP therapy, the abnormal accumulation of 18FDG-PET scan disappeared. However, disturbance of consciousness occurred 6 months later and recurrence as multiple brain tumors was detected. Although salvage chemotherapy was performed, the patient died of overwhelming sepsis. Primary peripheral nerve neurolymphomatosis is extremely rare. Early distinct diagnosis using 18FDG-PET and combination chemotherapy of rituximab and high dose methotrexate may improve the outcome for such patients.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 51 (7), 564-567, 2010

    The Japanese Society of Hematology

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