特発性血小板減少性紫斑病に対するビンクリスチンの効果

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書誌事項

タイトル別名
  • Effect of Vincristine in Idiopathic Thrombocytopenic Purpura
  • 持発性血小板減少性紫斑病に対するビンクリスチンの効果
  • ジハツセイ ケッショウバン ゲンショウセイ シハンビョウ ニ タイスル ビンク

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抄録

Treatment with Vincristine was assessed in eleven patients with idiopathic thrombocytopenic purpura. Nine of them had previously been refractory to glucocorticoid, and two of which had also been refractory to immunosuppressants. Vincristine was given intravenously in a dose of 1 or 2 mg every seventh or tenth day. There were two good, three fair and six poor results. Two good responders were given 2 mg Vincristine per week. In other nine patients, who were given 1 mg Vincristine every week, three responded fairly well and six responded poorly. Platelet count increased in a week after Vincristine injection in a 1 mg dose or 2 mg dose, and more increase was observed in a 2 mg dose. Two good responders complained of severe peripheral neuropathy, and therefore Vincristine had to be stopped. Platelet count in these patients fell soon after the discontinuation of Vincristine.<br>Our result of treatment with Vincristine in idiopathic thrombocytopenic purpura has been poor as compared with the report described by Ahn et al, and may be worse than that of other immunosuppressants. However, platelet response is more prompt with Vincristine than with other immunosuppressants. Further investigations are required to evaluate Vincristine in the treatment of idiopathic thrombocytopenic purpura.

収録刊行物

  • 臨床血液

    臨床血液 17 (12), 1261-1265, 1976

    一般社団法人 日本血液学会

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