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- MARUYAMA Dai
- Department of Hematology, National Cancer Center Hospital
Bibliographic Information
- Other Title
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- 造血器悪性腫瘍に対する免疫チェックポイント阻害薬
- ゾウケツキ アクセイ シュヨウ ニ タイスル メンエキ チェックポイント ソガイヤク
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Abstract
<p>Immuno-checkpoint inhibitors are one of the most promising immunotherapies for various advanced cancers including hematologic malignancies. Recently, enhanced signaling of the PD-1/CTLA4 pathway has emerged as a critical mechanism by which tumors can escape the anti-tumor immune response. PD-1-blocking antibodies have been used to enhance immunity in several malignancies and obtain durable responses, especially in patients with heavily treated relapsed/refractory Hodgkin lymphoma. Currently, several clinical trials including single agent or combination therapies for hematologic malignancies, such as Hodgkin lymphoma, B-cell lymphomas and multiple myeloma, are ongoing. The results of ongoing and future clinical trials may establish a new treatment paradigm for hematologic malignancies.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 57 (11), 2381-2387, 2016
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390001205036084224
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- NII Article ID
- 130005433510
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 027766735
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- PubMed
- 27941289
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed