A case of an anti-SRP myopathy with enlargement of the thymus

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  • Ohta Rie
    Section of Neurology, Japanese Red Cross Nagasaki Genbaku Hospital Present Address: Department of First Internal Medicine, Nagasaki University Hospital
  • Mukaino Akihiro
    Section of Neurology, Japanese Red Cross Nagasaki Genbaku Hospital Present Address: Department of First Internal Medicine, Nagasaki University Hospital
  • Kinoshita Ikuo
    Section of Neurology, Japanese Red Cross Nagasaki Genbaku Hospital
  • Tsujihata Mitsuhiro
    Section of Neurology, Nagasaki-Kita Hospital
  • Suzuki Shigeaki
    Department of Neurology, School of Medicine, Keio University

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Other Title
  • 胸腺腫大をともなう抗signal recognition particle抗体陽性ミオパチーの1例
  • 症例報告 胸腺腫大をともなう抗signal recognition particle抗体陽性ミオパチーの1例
  • ショウレイ ホウコク キョウセン シュダイ オ トモナウ コウsignal recognition particle コウタイ ヨウセイ ミオパチー ノ 1レイ

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Abstract

A 54-year-old female was admitted to our hospital because of the Raynaud phenomenon and muscle weakness of the upper limbs. The neurological findings showed somatic and proximal limb weakness. Laboratory studies showed a high serum creatine kinase level. Computerized tomography (CT) revealed enlargement of the thymus. A muscle biopsy showed a small number of degenerating and regenerating fibers but no inflammatory infiltrations. At first, she was initially treated with a three-day course of intravenous methylprednisolone (1 g/day). However, the weakness progressed and the serum creatine kinase level remained high. She was subsequently treated with a combination of tacrolimus (3 mg/day) and prednisolone, but showed no any improvement of the muscle weakness. Following additional treatment with intravenous immunoglobulin, she showed improvement in her muscle weakness. Further, anti-signal recognition particle antibodies were identified after treatment. There have been no previous reports of myopathy with antibodies against the signal recognition particle and enlargement of the thymus, so we herein report the details of this unique case.

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 54 (10), 798-802, 2014

    Societas Neurologica Japonica

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