New international classification of epilepsy and new antiepileptic drugs for medically intractable epilepsy

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  • Tsuji Sadatoshi
    Department of Neurology, University of Occupational and Environmental Health, School of Medicine

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Other Title
  • 教育講演１　新しいてんかん分類と抗てんかん薬の使い方
  • 教育講演 新しいてんかん分類と抗てんかん薬の使い方
  • キョウイク コウエン アタラシイ テンカン ブンルイ ト コウテンカンヤク ノ ツカイカタ

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Description

The task force of the international league against epilepsy (ILAE) proposed the "Diagnostic scheme for people with epileptic seizures and epilepsy" in 2001. The 2001 diagnostic scheme was updated in 2006. The ILAE Core Group recommended the new classification to replace the previous one (ILAE, 1981, 1989). However, the new classification is too complex to use for clinicians except expert epileptologists.<br> About 10 new antiepileptic drugs are launched recently. Among them, gabapentine, topiramate, and lamotrigine have been approved in Japan as adjunctive therapy for medically intractable seizures. The advantage of the new antiepileptic drugs includes newer mechanism of action, broad spectrum of anti-seizure effects, fewer side effects, and lesser drug interactions. The rational polytherapy is necessary for refractory epilepsy. The majority of elderly patients with new onset epilepsy become seizure free on antiepileptic monotherapy, often with modest dose.<br> We are now in the new era of epilepsy treatment.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 49 (11), 769-773, 2009

    Societas Neurologica Japonica

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