神経症状と汎発性血管内凝固症候群を伴なった骨髄原性悪性細網症の1例

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タイトル別名
  • An Autopsy Case of Myelogenous Malignant Reticulosis Associated with Neurologic Symptoms and Disseminated Intravascular Coagulation
  • シンケイ ショウジョウ ト ハンパツセイ ケッカンナイ ギョウコ ショウコウグ

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抄録

An autopsy case of myelogenous malignant reticulosis associated with neurologic manifestation was presented. The 67-year-old woman was admitted to the hospital because of anemia and marked hepatosplenomegaly. There was no lymphadenopathy. Hematologic and ferrokinetic studies revealed that she had a severe pancytopenia with leukoerythroblastosis and an extramedullary hematopoiesis. A biopsied iliac bone specimen showed the reticulum cell proliferation. From these findings she was diagnosed as myelogenous malignant reticulosis. Three and a half months after admission flaccid paraplegia with paresthesia suddenly occurred, and was followed by disseminated intravascular coagulation, acute bronchopneumonia and acute renal failure. She died approximately five months after the onset of symptoms.<br>Pathologic findings were as follows: malignant proliferation of atypical mononuclear cells involved almost all bone marrows. The spinal cord was compressed at the inferior thoracic and lumbar region and partly surrounded with the epidural infiltration of tumor cells, and was necrotic and softening.<br>Finally, the characteristic figures observed in the patient's clinical course were discussed from the autopsy findings.

収録刊行物

  • 臨床血液

    臨床血液 18 (11), 1355-1362, 1977

    一般社団法人 日本血液学会

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