A Case of Acute Myelogenous Leukemia and Brain Tumor Formation in Complete Remission

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  • 完全寛解中，脳内腫瘤を形成した急性骨髄性白血病の1例
  • カンゼン カンカイチュウ ノウナイ シュリュウ オ ケイセイシタ キュウセイ

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Abstract

A 50-year-old man was admitted to the Dept. of Hematology, Nagasaki University Hospital with a diagnosis of acute myelogenous leukemia on 19 Feb. 1975. He was put on a new DCVP (Daunomycin, Cytosine arabinoside, Vincristine and Predonisolone) schedule and got a complete remission after 2 months. In mid-June 1976, right incomplete hemiplegia accompanied by left temporo-parietal syndrom developed, though complete remission still continued hematologically. Electroencephalography showed diffuse slow waves and brain scanning revealed hot area in left Sylvius area. Meningeal leukemia had coexisted. On 13 July 1976, a partial resection of the brain tumor was done. The color of tumor was not green, but yellowish white. Histology of tumor tissue was compatible with myeloblastoma. Microscopy revealed an increase in reticulin by Wilder's stain and elcctron microscopy showed an increase in collagen and reticular fiber. Strong positive peroxidase was seen on stamp preparation. Post non radical operation, liniac irradiation therapy was done to entire brain (3,000 rads in total amount). The patient's general condition became gradually worse and he died on 15 Dec. 1976. Postmortem examination of the brain revealed scattered leukemic cells in the hypothalamus.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 18 (11), 1349-1354, 1977

    The Japanese Society of Hematology

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