Blind loop syndromeによる巨赤芽球性貧血の1例

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書誌事項

タイトル別名
  • A Case of Blind Loop Syndrome with Megaloblastic Anemia
  • Blind loop syndrome ニヨル キョセキガキュウセイ ヒンケツ

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抄録

A case of blind loop syndrome with megaloblastic anemia in a 21-year-old female who had been operated on lateral jejuno-transversostomy 8 years prior to the onset of the illness was reported.<br>Laboratory examinations revealed pancytopenia with hyperchromic macrocytic anemia in the peripheral blood and the presence of a number of megaloblasts and giant metamyelocytes in the bone marrow. X-ray findings of the gastrointestinal tract showed an anastomosis between the transverse colon and the jejunum at the hepatic flexure. Serum vitamin B12 level was remarkably low. Schilling test of urinary excretion of radioactive vitamin B12 revealed decreased absorption of vitamin B12 with no response to the administration of the intrinsic factor.<br>The large doses of vitamin B12 resulted in a sharp rise in reticulocytes followed by a simultaneous increase in hemoglobin, RBC, WBC and platelet counts, and disappearance of megaloblasts and giant metamyelocytes in the bone marrow.<br>A side-to-side jejuno-transversostomy and a blind loop was restored by the re-operation.<br>The patient has been in a state of good hematological remission 3 years after operation.

収録刊行物

  • 臨床血液

    臨床血液 18 (11), 1343-1348, 1977

    一般社団法人 日本血液学会

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