Autoimmune hemolytic anemia in a patient with idiopathic interstitial pneumonia

  • FUKUDA Kuniyoshi
    Department of Clinical and Experimental Hematology, University of Tsukuba
  • YOKOYAMA Yasuhisa
    Department of Clinical and Experimental Hematology, University of Tsukuba
  • KAMADA Yuhei
    Department of Clinical and Experimental Hematology, University of Tsukuba
  • TAOKA Kenichi
    Department of Clinical and Experimental Hematology, University of Tsukuba
  • SUZUKAWA Kazumi
    Department of Clinical and Experimental Hematology, University of Tsukuba
  • CHIBA Shigeru
    Department of Clinical and Experimental Hematology, University of Tsukuba

Bibliographic Information

Other Title
  • 特発性間質性肺炎に合併した自己免疫性溶血性貧血
  • 症例報告 特発性間質性肺炎に合併した自己免疫性溶血性貧血
  • ショウレイ ホウコク トクハツセイ カンシツセイ ハイエン ニ ガッペイ シタ ジコ メンエキセイ ヨウケツセイ ヒンケツ

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Description

We report a rare case of autoimmune hemolytic anemia (AIHA) complicated by idiopathic interstitial pneumonia (IIP). A sixty-year-old man was diagnosed as having IIP in January 2009. In March, when he was hospitalized for the introduction of home oxygen therapy, severe anemia was detected. Based on the findings showing elevated levels of lactate dehydrogenase and indirect bilirubin, a decreased level of haptoglobin, positive Coombs test, and splenomegaly, a diagnosis of AIHA was made. Although anti-DNA antibody was found, diagnostic criteria for systemic lupus erythematosus and other collagen diseases were not fulfilled. Therefore, we concluded that AIHA coexisted with IIP. Treatment with prednisolone led to improvement of both AIHA and IIP. There has not been any exacerbation even after a gradual reduction of prednisolone to 7.5 mg/day. Coexistence of AIHA and IIP is rare, and accumulation of case reports is needed to gain a better understanding of this condition.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 52 (1), 14-17, 2011

    The Japanese Society of Hematology

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