播種性好酸性膠原病の1例

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書誌事項

タイトル別名
  • A Case of Disseminated Eosinophilic Collagen Disease
  • ハシュセイ コウサンセイ コウゲンビョウ ノ 1レイ

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抄録

A 57-year-old miner was admitted with complaint of the rash on his both arms. A diagnosis of pulmonary silicosis had been made since five years ago, but there were no signs of drug or food allergy. A blood examination revealed leucocytosis with eosinophilia, but no eosinophilia was detected among his family and relatives. Since five years ago, he had been suffering from swelling in the neck, difficulty in swallowing, and slight dyspnea. Physical examination on admission revealed atopic dermatitis and rales on his both lungs. The laboratory findings were as follows: WBC 8600/cmm with 18% eosinophilia, IgG (λ) M-protein, IgG 2320 mg/ml, IgA 300 mg/ml, and normal levels of IgD, IgM, and IgE. Antinuclear antibody was negative. Antilung antibody was positive. Tests for cellular immunity revealed positive tests for PPD and DNCB, and subpopulation of peripheral lymphocyte was normal, however, blastoid transformation of PHA was increased. The immunological tests for parasitic infestation were negative. The skin biopsy demonstrated perivascular eosinophilic infiltration in the dermis. After discontinuation of prednisolone, leucocytosis (49600/cmm) with 85% eosinophilia recurred with general symptoms. An administration of prednisolone was effective to improve the above-mentioned signs and symptomes.

収録刊行物

  • 臨床血液

    臨床血液 17 (11), 1198-1206, 1976

    一般社団法人 日本血液学会

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