Air-leak syndrome in patients with non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation

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  • ENAKA Makiko
    Department of Hematology, Kanagawa Cancer Center Department of Pathology, Yokohama City University Medical Center
  • HAGIHARA Maki
    Department of Hematology, Kanagawa Cancer Center
  • SAKAI Rika
    Department of Hematology, Yokohama City University Medical Center
  • OSHIMA Rika
    Department of Hematology, Yokohama City University Medical Center
  • ITO Satomi
    Department of Hematology, Kanagawa Cancer Center
  • MOTOHASHI Kenji
    Department of Hematology, Kanagawa Cancer Center
  • MARUTA Atsuo
    Department of Hematology, Kanagawa Cancer Center
  • ISHIGATSUBO Yoshiaki
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • KANAMORI Heiwa
    Department of Hematology, Kanagawa Cancer Center

Bibliographic Information

Other Title
  • 同種造血幹細胞移植後の非感染性肺病変に合併したair-leak syndrome
  • 症例報告 同種造血幹細胞移植後の非感染性肺病変に合併したair-leak syndrome
  • ショウレイ ホウコク ドウシュ ゾウケツ カンサイボウ イショクゴ ノ ヒカンセンセイ ハイ ビョウヘン ニ ガッペイシタ air leak syndrome

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Description

We reported 5 patients who developed air-leak syndrome (ALS) including pneumothorax, pneumomediastinum and subcutaneous emphysema after allogeneic stem cell transplantation (SCT). The underlying diseases were AML (n=2), ALL (n=1), MDS (n=1), and CML (n=1). All patients received allogeneic SCT from related donors including 2 donors with HLA mismatch. Total body irradiation was performed as a conditioning regimen in all patients. Late-onset noninfectious pulmonary complications (LONIPC) were detected in all patients before the development of ALS. The interval from diagnosis of LONIPC to onset of ALS was 10-360 days (median, 20 days). Four of 5 patients were treated with corticosteroid for chronic graft-versus-host disease and/or LONIPC. To date, three patients have died of respiratory failure. The others are currently alive and one of these surviving patients is receiving home oxygen treatment. Physicians should be aware of this rare complication following LONIPC, because treatment of ALS is difficult in some patients.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 50 (1), 39-43, 2009

    The Japanese Society of Hematology

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