Multiple Myeloma

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  • NAKATSUJI Tadako
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • MATSUMOTO Noboru
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • KAKU Kohei
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • HIROSHIGE Yukio
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • ODA Susumu
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • SHINOHARA Kenji
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • 中島 弘二
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • 小林 勝昌
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • YAGA Ken
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • FUJII Shinya
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • MIWA Shiro
    Third Department of Internal Medicine, Yamaguchi University School of Medicine
  • KAMEI Toshiaki
    First Department of Pathology, Yamaguchi University School of Medicine
  • NAGASAWA Takaaki
    First Department of Pathology, Yamaguchi University School of Medicine
  • TANI Shigeki
    Second Department of Pathology, Yamaguchi University School of Medicine

Bibliographic Information

Other Title
  • 多発性骨髄腫
  • 多発性骨髄腫--Melphalan療法と予後因子
  • タハツセイ コツズイシュ Melphalan リョウホウ ト ヨゴ インシ
  • —Melphalan療法と予後因子—
  • —Effect of Melphalan and Prognostic Factors—

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Abstract

Effect of Melphalan and prognostic factors were evaluated in the patients with multiple myeloma.<br>Effect of Melphalan was examined in 33 patients who were treated with intermittent courses of Melphalan-Prednine combination (MP therapy). Good response to MP therapy was obtained in 24 cases out of 33 cases, while 9 cases did not respond to MP therapy. The most remarkable effect was decrease of plasma cells in the bone marrow aspirates.<br>The prognostic significance of laboratory data on admission and clinical features has been analysed in all 34 cases. Low hemoglobin concentration, increased ratio of plasma cells in the bone marrow, hypercalcemia, high serum uric acid level, hypoalbuminemia, excretion of Bence Jones protein in urine and light chain of λ type were all associated with shortened lifespan. The statistical analysis confirmed that low hemoglobin level (less than 10 g/100 ml), increased plasma cell count (more than 20%) and hypoalbuminemia (less than 2.5 g/100 ml) were strongly correlated with a poor prognosis (p<0.05). As complications of multiple myeloma, infection and uremia were frequent and these two were main causes of death. Postmortem examination in 15 cases revealed myeloma kidney in 8 cases and pulmonary infection in 8 cases. Infections and uremia were considered to affect the survival of the patients with this disorder.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 21 (3), 347-355, 1980

    The Japanese Society of Hematology

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